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Wegener 氏肉芽肿(WG)是以上下呼吸道坏死性肉芽肿、血管炎、坏死性半月型肾小球肾炎为特征的全身性疾病。早期诊断及时给予环磷酰胺、皮质醇治疗可改善预后。基于该病复发多而提倡的环磷酰胺长期疗法,不仅仍有复发,且有副作用。WG 与抗中性粒细胞胞浆抗体(ANCA)关系密切,WG 复发前 ANCA明显升高。作者根据这一关系,设立对照组,研究早期诊断、治疗方案。每3个月观察一
Wegener’s granulomatosis (WG) is a systemic disease characterized by necrotizing granuloma of the upper and lower respiratory tract, vasculitis, and necrotizing hemimorphic glomerulonephritis. Early diagnosis of timely delivery of cyclophosphamide, cortisol treatment can improve the prognosis. Long-term treatment of cyclophosphamide, which is advocated based on the recurrence of the disease, not only causes recurrence but also has side effects. WG and anti-neutrophil cytoplasmic antibody (ANCA) are closely related, ANCA before WG recurrence was significantly higher. According to this relationship, the authors set up a control group to study early diagnosis and treatment programs. One observation every 3 months