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法洛四联症根治术早期死亡率较先进的心脏中心已控制在1%～2%左右,但远期预后仍待观察。文献报道,随着随访时间延长,右心室功能不全、房室性心律失常等并发症也随之增多加重,常有心律失常性猝死等报道,而其主要与肺动脉瓣反流这一重要病理生理变化有关;重度肺动脉瓣反流还需要采取肺动脉瓣置换术方式来解决,而对预防肺动脉瓣反流的手术方式和材料还在积极探索中。现就近年来法洛四联症患儿的远期死亡率及原因、远期并发症、重要病理生理变化、材料探索及瓣膜置换的研究进展做一综述。
Tetralogy of Fallot early radical mortality rate of advanced cardiac center has been controlled at 1% to 2%, but the long-term prognosis remains to be seen. Reported in the literature, with the extension of follow-up, right ventricular dysfunction, atrioventricular arrhythmias and other complications also will be increased, often sudden arrhythmia and other reports, and its main and pulmonary valve regurgitation this important pathophysiology Changes; severe pulmonary valve regurgitation also need to take pulmonary valve replacement to solve, and to prevent pulmonary valve regurgitation surgery methods and materials are still actively explored. The recent progress in the study of long-term mortality and its causes, long-term complications, important pathophysiological changes, material exploration and valve replacement in children with tetralogy of Fallot is reviewed.