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目的 :T淋巴瘤侵袭转移诱导因子1(TIAM1)的高表达在多种人类恶性肿瘤中均有报道,但其在口腔鳞癌的表达却少有研究,本文旨在探讨TIAM1在口腔鳞癌中的表达及临床意义。方法:采用免疫组织化学法检测80例口腔鳞癌组织及20例正常口腔黏膜组织中TIAM1蛋白的表达情况,并分析相关的临床病理因素。采用SPSS19.0软件包对数据进行统计学分析。结果:TIAM1蛋白在口腔鳞癌组织中的阳性表达率(91.25%)显著高于正常口腔黏膜组织(10.00%);口腔鳞癌组织中TIAM1蛋白的表达与患者的性别、年龄无关,而与病理分级(P=0.019)、不同临床分期(P<0.001)、淋巴结转移(P=0.004)显著相关。结论 :TIAM1的表达与口腔鳞癌的发生、发展、转移密切相关。
Objective: T lymphoma invasion and metastasis inducing factor 1 (TIAM1) high expression in a variety of human malignancies have been reported, but its expression in oral squamous cell carcinoma is rarely studied, this paper aims to investigate the expression of TIAM1 in oral squamous cell carcinoma Expression and clinical significance. Methods: The immunohistochemical method was used to detect the expression of TIAM1 protein in 80 cases of oral squamous cell carcinoma and 20 cases of normal oral mucosa tissues, and to analyze the related clinicopathological factors. SPSS19.0 software package for statistical analysis of the data. Results: The positive expression rate of TIAM1 protein in oral squamous cell carcinoma was significantly higher than that in normal oral mucosa (91.25%) (10.00%). The expression of TIAM1 protein in oral squamous cell carcinoma was not related to sex and age, (P = 0.019), different clinical stages (P <0.001), lymph node metastasis (P = 0.004) were significantly correlated. Conclusion: The expression of TIAM1 is closely related to the occurrence, development and metastasis of oral squamous cell carcinoma.