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在美国休斯顿召开的细胞生长及分化的介质专题讨论会上研究人员认为,癌基因和天然生长因子之间的关系有力地证明恶性细胞和正常细胞均以同样的途径不断增殖。据参加专题讨论会的科学家称,没有一个人对于肿瘤的发生可得出一准确的结论,但是揭示一系列代谢链有助于缩小肿瘤研究的中心课题。由于1983年发现癌基因蛋白,引起了科学家们的乐观和兴趣。这种蛋白类似血小板衍生的生长因子(PDGF),即血凝时产生的一种多肽。上述发现为癌基因和巳知的生物功能之间提供了第一个直接的联系。1984年初,美国、英国和以色列科学家发现了第二个联系,即:与小鸡白血病有关的癌基因产生了一种物质, 其氨基酸顺序与表皮生长因子(EGF)受体的氨基酸顺序相似。 Stuart A Aaronson说,PDGF和EGF与癌基因的联系是已累积的证据中的一部分,提示正常细胞和恶性细胞的生长如果不完全一
At the media symposium on cell growth and differentiation held in Houston, USA, the researchers believe that the relationship between oncogenes and natural growth factors strongly proves that both malignant and normal cells continue to proliferate in the same way. According to scientists who participated in the symposium, no one can come to an accurate conclusion about the occurrence of cancer, but revealing a series of metabolic chain helps to narrow the central issue of cancer research. The discovery of oncogene proteins in 1983 caused the optimism and interest of scientists. This protein is similar to platelet-derived growth factor (PDGF), a polypeptide produced during blood clotting. The above findings provide the first direct link between oncogenes and known biological functions. In early 1984, scientists from the United States, the United Kingdom, and Israel discovered a second link: the oncogene associated with chick leukemia produces a substance whose amino acid sequence is similar to that of the epidermal growth factor (EGF) receptor. Stuart A Aaronson said that the association of PDGF and EGF with oncogenes is part of the evidence that has accumulated, suggesting that normal and malignant cells grow incompletely.