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目的探讨炔雌醇环丙孕酮片联合二甲双胍治疗多囊卵巢综合征(PCOS)患者的临床效果。方法选取2015年7月至2016年6月于吉林省白城中心医院就诊的58例PCOS患者作为研究对象,按随机数字表法将其分为试验组与对照组,每组29例。对照组患者给予炔雌醇环丙孕酮片,试验组患者在对照组基础上辅以二甲双胍治疗。观察两组患者内分泌激素变化情况,比较其妊娠率、自然排卵率、不良反应发生情况。结果用药后,试验组患者促黄体生成素(LH)、睾酮(T)水平均明显低于对照组,差异均有统计学意义(均P<0.05),两组患者催乳素(PRL)、基础卵泡刺激素(FSH)水平差异均无统计学意义(均P>0.05);试验组患者排卵率及自然妊娠率均明显高于对照组,差异均有统计学意义(均P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论对PCOS患者联用炔雌醇环丙孕酮片、二甲双胍,可有效改善内分泌激素水平,提高排卵效果,增加受孕概率,且安全性较高。
Objective To investigate the clinical effect of ethinyl estradiol cyproterone tablets combined with metformin in patients with polycystic ovary syndrome (PCOS). Methods Fifty-eight patients with PCOS who were treated in Baicheng Central Hospital of Jilin Province from July 2015 to June 2016 were selected as study subjects and divided into experimental group and control group according to random number table method, with 29 cases in each group. Patients in the control group were given ethinyl estradiol cyproterone tablets. Patients in the test group were supplemented with metformin on the basis of the control group. The changes of endocrine hormones in both groups were observed. The pregnancy rate, the natural ovulation rate and the incidence of adverse reactions were compared. Results After treatment, the levels of luteinizing hormone (LH) and testosterone (T) in the test group were significantly lower than those in the control group (all P <0.05). The levels of prolactin (PRL) (All P> 0.05). The ovulation rate and spontaneous pregnancy rate in the test group were significantly higher than those in the control group (all P <0.05). The difference between the two groups was statistically significant There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusions PCeth in patients with ethinyl estradiol cyproterone tablets, metformin, can effectively improve the level of endocrine hormones, improve ovulation effect, increase the probability of conception, and high safety.