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目的 研究接受室溶液电导率对离子导入渗透速率的影响和作用机理。方法 以盐酸丁卡因为模型药物 ,采用Valia chien双室扩散池 ,供应室组成恒定 ,分别测定不同组成和不同浓度的接受室溶液下的离子导入渗透速率 ,并测定供应室和接受室的离子电导率。结果 盐酸丁卡因离子导入渗透随着接受室阴离子 (Cl- )浓度的减少而增加。当电流强度恒定 ,盐酸丁卡因的离子导入增渗倍数 (ER ,ER =离子导入渗透速率 被动扩散渗透速率 )与供应室和接受室电导率和的倒数 [1 (ks.d+ks .r) ,ks.d和ks.r分别是供应室和接受室的电导率 ]成线性关系。结论 接受室离子电导率可能是离子导入的重要影响因素
Objective To study the influence of the conductivity of the solution in the receiving chamber on the infiltration rate of iontophoresis and its mechanism. Methods Tetracaine hydrochloride was used as a model drug. Valia chien double-chamber diffusion cells were used. The composition of the donor compartment was constant. The iontophoresis rate under different composition and different concentrations of the acceptor compartment solution was determined. The ion conductivity of the donor compartment and the donor compartment was determined. rate. Results The tetracaine hydrochloride iontophoresis increased with the reduction of the acceptor anion (Cl-) concentration. When the amperometric intensity is constant, the iontophoresis multiplication factor of tetracaine hydrochloride (ER, ER = passive diffusion permeation rate of iontophoresis permeation rate) is inversely proportional to the inverse of the sum of conductivity of donor and receiver compartments [1 (ks.d + ks .r ), ks.d and ks.r are the conductivity of the supply and receiver compartments, respectively. Conclusions Receiving chamber ionic conductivity may be an important factor for iontophoresis