H_2受体拮抗剂维持治疗可减少溃疡复发。本文研究长期使用是否会有持久阻滞H_2受体的危险。方法选用6例男性病人,年龄33～62岁,无烟酒癖,经内镜证实十二指肠溃疡已经用H_2受体拮抗剂治愈。先检查病者维持治疗前的H_2受体敏感性。方法是让病者每晚口服雷尼替丁(ranitidine)150mg共3晚。然后在末次服药之后10h给H_2受体特异促效药双咪硫胍(impromidine),以刺激胃酸分泌。最初滴注2.5μg/kg/h共90min,然后加倍滴注5μg/ H 2 receptor antagonist maintenance treatment can reduce ulcer recurrence. This article examines the long-term use of whether there is a long-term risk of blocking H 2 receptors. Methods Six male patients, aged 33-62 years, were selected as non-alcoholic addicts. Duodenal ulcer confirmed by endoscopy was cured by H 2 receptor antagonist. First check the patient to maintain H 2 receptor sensitivity before treatment. The method is to allow the patient to take ranitidine 150 mg orally for 3 nights each night. The H 2 receptor specific agonist, impromidine, is then administered 10 h after the last dose to stimulate gastric acid secretion. 2.5 μg / kg / h was initially instilled for a total of 90 min followed by a double infusion of 5 μg /