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用21只家兔随机分为中药组,病态组与正常组。前两组每兔惑染日本血吸虫尾蚴120±1条经70天形成肝纤维化后左吡喹酮杀虫。中药组灌服益气活血复方口服液,治疗3个月后观察各组肝细胞、贮脂细胞、成纤维细胞及Disse腔超微结构变化。结果发现该药对改善肝组织细胞超微结构病理、抑制贮脂细胞向成纤维细胞转化及胶原合成具有较好效果。提示益气活血复方有抗肝纤维化作用。
21 rabbits were randomly divided into Chinese medicine group, morbid group and normal group. The first two groups of rabbits were contaminated with 120±1 cercariae of Schistosoma japonicum and the left praziquantel insecticide was used after hepatic fibrosis was formed for 70 days. The Chinese medicine group was fed with Yiqi Huoxue compound oral liquid. After 3 months of treatment, ultrastructural changes of hepatocytes, lipid-storing cells, fibroblasts, and Disse cavity were observed. The results showed that the drug had a good effect on improving the ultrastructural pathology of hepatic cells, inhibiting the conversion of fat-storing cells to fibroblasts and collagen synthesis. Tip Yiqi Huoxue compound has anti-liver fibrosis effect.