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目的 探讨紫外线照射充氧自血回输（ＵＢＩＯ） 对急性脑梗塞患者循环血中肿瘤坏死因子（ＴＮＦ）、内皮素（ＥＴ） 含量的影响。方法 ６０ 例急性脑梗塞患者随机分为ＵＢＩＯ 综合治疗组与常规治疗组各３０ 例，采用放免法分别测定两组患者治疗前及治疗２０ ｄ 后ＴＮＦ、ＥＴ 含量。结果 ＵＢＩＯ组治疗前ＴＮＦ、ＥＴ 含量分别为（０．９８±０ ．５６）ｎｇ／ｍｌ、（７４ ．８６ ±２５ ．７２）ｐｇ／ｍｌ，治疗２０ ｄ 后ＴＮＦ、ＥＴ 含量显著下降，分别为（０．６１±０．４５）ｎｇ／ｍｌ、（５６ ．３２ ±２１．３３）ｐｇ／ｍｌ（ Ｐ＜ ０ ．０１） ，而常规治疗组下降无显著性（Ｐ＞ ０．０５） 。结论 ＵＢＩＯ 能从多方面干预ＴＮＦ、ＥＴ 的释放。
Objective To investigate the effects of UBIO on the levels of tumor necrosis factor (TNF) and endothelin (ET) in patients with acute cerebral infarction. Methods Sixty patients with acute cerebral infarction were randomly divided into UBIO treatment group and conventional treatment group, 30 cases in each group. The levels of TNF and ET before treatment and after 20 days of treatment were determined by radioimmunoassay. Results The levels of TNF and ET in UBIO group before treatment were (0.98 ± 0.56) ng / ml and (74.86 ± 25.72) pg / ml, respectively. After 20 days of treatment, the contents of TNF and ET were significantly decreased (0.61 ± 0.45) ng / ml and (56.32 ± 21.33) pg / ml, respectively (P <0.01), but no significant difference was found between the two groups (P> 0.05). Conclusion UBIO can intervene in the release of TNF and ET in many aspects.