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目的研究EGFR、CEA和P53在胃癌组织中的表达与临床病理特征的关系。方法选择2012年10月—2014年9月收治的胃癌患者104例,将手术切除的胃癌标本104份作为研究组,另随机抽取54例胃癌患者的切缘正常组织54份作为对照组,观察EGFR、CEA和P53的表达与临床病理特征的关系。结果 EGFP、CEA、P53表达均与胃癌浸润深度、淋巴结转移有明显关系;EGFP的表达、P53蛋白表达与胃癌的病理分期有明显关系;EGFP的表达与胃癌的分化程度有明显关系。结论胃癌患者的EGFR、CEA和P53均有表达,可以对EGFR、CEA和P53联合检测,从而能有效诊断、治疗胃癌并且能评估胃癌患者的预后效果。
Objective To study the relationship between the expression of EGFR, CEA and P53 in gastric carcinoma and clinicopathological features. Methods 104 patients with gastric cancer admitted to our hospital from October 2012 to September 2014 were enrolled in this study. 104 patients with resected gastric cancer were selected as the study group, and 54 normal tissues from 54 patients with gastric cancer were selected as the control group. EGFR , CEA and P53 expression and clinicopathological features. Results The expressions of EGFP, CEA and P53 were significantly correlated with the depth of invasion and lymph node metastasis. The expression of EGFP and the expression of P53 protein were significantly correlated with the pathological stage of gastric cancer. The expression of EGFP was significantly correlated with the differentiation of gastric carcinoma. Conclusion The expression of EGFR, CEA and P53 in patients with gastric cancer can be detected by combined detection of EGFR, CEA and P53, which can effectively diagnose and treat gastric cancer and evaluate the prognosis of patients with gastric cancer.