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目的:探讨米索前列醇联合缩宫素应用预防产后出血的效果。方法:以本院分娩的180例自然分娩孕妇为研究对象,随机分为观察组和对照组,观察组在孕妇分娩后给予米索前列醇+缩宫素联合用药,缩宫素经肌肉注射,米索前列醇经舌下含化,对照组在孕妇分娩后只给予缩宫素肌肉注射,观察两组患者在产后2小时的出血量、产后出血发生率、用药前后血压变化及不良反应发生率等方面的差异。结果:观察组患者的产后出血量显著少于对照组(P<0.05),产后出血发生率也明显低于对照组(P<0.05),两组患者的用药前后血压变化均无明显差异(P>0.05),不良反应发生率两组间无明显差异(P>0.05)。结论:米索前列醇联合应用缩宫素可显著减少产妇产后的出血量,降低产后出血的发生率,不会引起产妇明显的血压变化,并且不会增加不良反应发生率,是一种安全、有效的治疗方法,具有较高的临床应用价值。
Objective: To investigate the effect of misoprostol combined with oxytocin in preventing postpartum hemorrhage. Methods: 180 cases of spontaneous delivery of pregnant women in our hospital were randomly divided into the observation group and the control group. The observation group was given misoprostol + oxytocin combination therapy after delivery. The oxytocin was injected intramuscularly, Misoprostol was sublingual. In the control group, only oxytocin was given intramuscularly after delivery. The bleeding volume, the incidence of postpartum hemorrhage, the changes of blood pressure before and after treatment and the incidence of adverse reactions were observed in two groups after delivery And so on the difference. Results: The postpartum hemorrhage in the observation group was significantly less than that in the control group (P <0.05), and the incidence of postpartum hemorrhage was also significantly lower than that in the control group (P <0.05). There was no significant difference in blood pressure between the two groups before and after treatment (P > 0.05), no significant difference between the two groups (P> 0.05). Conclusion: The combination of misoprostol and oxytocin can significantly reduce the amount of postpartum hemorrhage, reduce the incidence of postpartum hemorrhage, will not lead to significant changes in blood pressure, and will not increase the incidence of adverse reactions, is a safe, Effective treatment, has a high clinical value.