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目的：观察谷氨酸类受体激动剂卡因酸（ＫＡ）对豚鼠耳蜗的毒性作用。方法：健康杂色豚鼠８只，每只动物经圆窗膜给予６０ｍＭＫＡ１μｌ，于用药前及用药后１２ｈ分别检测听神经复合动作电位（ＣＡＰ），耳蜗微音电位（ＣＭ）和畸变产物耳声发射（ＤＰＯＡＥ）之２ｆ１－ｆ２。结果：用药后ＣＡＰ明显下降或消失（Ｐ＜０．００１），而ＣＭ和ＤＰＯＡＥ无明显变化。结论：ＫＡ对初级听觉传入神经末梢具有选择性毒性作用。
Objective: To observe the toxic effect of glutamic acid receptor agonist card acid (KA) on guinea pig cochlea. Methods: Eight healthy pigmented guinea pigs were randomly divided into 4 groups. Each animal was given 1μl of 60mM KA at round window membrane. The auditory nerve complex action potential (CAP), cochlear microphony potential (CM) and distortion product otoacoustic emission DPOAE) of 2f1-f2. Results: After treatment, CAP decreased or disappeared significantly (P <0.001), while CM and DPOAE did not change significantly. Conclusion: KA has a selective toxic effect on primary auditory afferent nerve terminals.