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益生菌与哺乳动物肠道的协同进化从根本上改变了哺乳动物的生理功能。An等报道,肠道脆弱拟杆菌(Bacteroides fragilis)通过提供独特的抑制性鞘脂类(sphingolipids)来补充宿主的内源性脂质抗原环境,从而调节宿主体内恒定型自然杀伤T细胞(invariant natural killer T cells,iNKT细胞)的内稳态。这个过程发生在生命的早期,并能有效地阻碍新生儿发育过程中iNKT细胞的增殖,因此结肠的iNKT细胞总数到成年期受到限制,使宿主免于罹患实验性iNKT细胞介导的、由噁唑酮诱导的
The synergistic evolution of probiotics and the mammalian gut has fundamentally altered mammalian physiology. An et al. Reported that Bacteroides fragilis plays an important role in regulating the host’s endogenous lipid antigen environment by providing unique inhibitory sphingolipids to regulate the invariant natural invadiant natural T cells killer T cells, iNKT cells). This process occurs early in life and can effectively hinder the proliferation of iNKT cells during neonatal development so that the total number of iNKT cells in the colon is limited to adulthood leaving the host free of experimental iNKT cell-mediated, Oxazolone induced