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巴比妥类药物广泛用于颅内高压、脑代谢性疾病、脑外伤、脑出血术前或术中麻醉。由于该类药物治疗指数低、误用率和滥用率高,极易引起中毒。因此,迅速准确地测定其体液内浓度,具有十分重要的临床意义。过去,人们多采用免疫法、气相色谱法测定硫贲妥和戊巴比妥的体液浓度,但由于代谢物的存在,免疫法缺乏足够的专一性和灵敏性,气相色谱法则由于高温时巴比妥类药物的降解以及样本处理过
Barbiturates are widely used in intracranial hypertension, cerebral metabolic diseases, traumatic brain injury, intracerebral hemorrhage preoperative or intraoperative anesthesia. Because of such low drug treatment index, misuse rate and abuse rate, can easily lead to poisoning. Therefore, the rapid and accurate determination of its body fluid concentration has a very important clinical significance. In the past, people used immunoassay, gas chromatography to determine the concentration of thiobenobu and pentobarbital body fluids, but due to the presence of metabolites, lack of sufficient specificity and sensitivity of immunological methods, gas chromatography due to high temperature Pakistan Biotech degradation and sample handling