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为了证实葡萄球菌A蛋白(SPA)是否能除去急性实验性血清病(AESS)家兔血浆中免疫复合物以减轻肾小球肾炎的病变,本实验设实验组和对照组,每组家兔各14只。实验组於注射抗原(BSA)后第8、10、12天抽血14ml/kg体重,分离血浆以金葡球菌Cowan Ⅰ株(含SPA)处理后,再将血浆与血球混匀输回原家兔体内;对照组家兔血浆以金葡球菌Wood 46株(不含SPA)处理后,再将血浆与血球混匀输回原家兔体内。结果证明:实验组动物与对照组动物相比,循环中BSA-抗BSA复合物显著减少,肾组织病变也显著减轻。充分说明SPA确能除去血浆中免疫复合物,从而减轻家兔肾小球肾炎的病变。为临床提供了一种治疗免疫复合物病的可行途径。
In order to confirm whether Staphylococcus A protein (SPA) can remove the immune complex of acute experimental sera (AESS) in rabbits to alleviate the pathological changes of glomerulonephritis, the experimental group and the control group, each group of rabbits 14 only. In the experimental group, 14ml / kg of body weight was drawn on the 8th, 10th and 12th days after the injection of antigen (BSA). The plasma was separated from the plasma by the Cowan Ⅰ Staphylococcus aureus (including SPA) Rabbits in vivo. The control rabbits’ plasma was treated with Staphylococcus aureus Wood 46 (SPA-free), then the blood plasma and blood cells were evenly mixed and returned to the original rabbits. The results showed that compared with the animals in the control group, the circulating BSA-anti-BSA complex was significantly reduced, and the renal tissue lesions were also significantly reduced. The full description of SPA can indeed remove the immune complexes in the plasma, thereby reducing the pathological changes of rabbit glomerulonephritis. It provides a feasible way for clinical treatment of immune complex diseases.