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目的探讨正常老年人与阿尔茨海默病(ALZHEIMER?SDISEASE,AD)患者不同区域大脑皮层中生长抑素(SO?MATOSTATIN,SOM)阳性神经元数量是否存在差异,以及这些神经元是否以细胞凋亡的方式死亡或消失.方法采用免疫组织化学方法观察SOM阳性神经元;采用TUNEL法观察细胞凋亡.结果正常老年人及AD病人大脑皮层不同区域内的SOM阳性神经元的数量未见显著性差异,但可见细胞凋亡.而SOM阳性神经元与TUNEL阳性细胞并不完全重叠出现.结论正常老年人及AD病人大脑皮层内SOM阳性神经元均较少,但两者之间无明显差异.细胞凋亡与SOM阳性神经元之间似无明显相关性.“,”Objective To study whether there were any difference in the distribution and in the number of somatostatin (SOM) positive neurons in several brain regions in the normal aging individuals and in the patients with Alzheimer?s disease (AD) and if there was any relationship between SOM positive neurons and apoptosis. Methods Immunohistochemistry was used to label SOM positive neurons and the terminal dUTP end labelling method was employed in the apoptosis ...