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给家兔静注黄连素后由ADP、花生四烯酸(AA)、胶原及钙离子载体A_(23187)引起的血小板聚集率明显降低。黄连素对低浓度A_(23187)诱导的胞外钙内流具有明显的抑制作用,对家兔静止血小板cAMP含量无明显影响。
After intravenous infusion of berberine, the platelet aggregation rate induced by ADP, arachidonic acid (AA), collagen and calcium ionophore A 23187 was significantly decreased. Berberine had a significant inhibitory effect on the extracellular calcium influx induced by low concentration of A_ (23187), but had no effect on cAMP content of resting platelets in rabbits.