前体药物(Pro-drug)已屡见报道。它可由两个具有已知活性的母体药物相结合或由一个母体药物结合一个无活性基团而形成。常以复盐、酯类等形式存在。前体药物进入体内可经酶作用或其他反应而释放出原生理活性物质,而发挥疗效。故又称为潜效药物,即药物的潜效化(Drug Latentiation)。前体药物由于改变了原母体药物的化学结构, Pro-drugs have been reported frequently. It can be formed by combining two parent drugs of known activity or by combining one parent drug with one inactive group. Often double salt, esters and other forms exist. Prodrugs enter the body through the enzyme or other reactions and release of the original physiologically active substances, and play a therapeutic effect. It is also known as the potential drug, that is drug drug (Drug Latentiation). Prodrugs change the chemical structure of the original parent drug,