论文部分内容阅读
目的:探讨肝癌患者手术前后血浆纤溶酶原(PLG)、α2-抗纤溶酶(α2-AP)活性,D-二聚体(D-Dimer)含量变化及其临床意义。方法:采用发色底物法对20例肝癌患者手术前后血浆PLG、α2-AP活性进行检测;同时胶体金双抗体夹心法检测血浆D-Dimer含量。结果:肝癌患者血浆PLG、α2-AP活性明显低于正常对照组(P<0.05)。肝癌患者血浆D-Dimer含量明显高于正常对照组(P<0.01)。术后血浆PLG、α2-AP活性较术前明显升高(P<0.05),血浆D-Dimer含量较术前明显降低(P<0.01)。结论:肝癌患者存在纤溶系统的激活,并随手术病情的好转而改善。
Objective: To investigate the changes of plasma plasminogen (PLG), α2-anti-plasmin (α2-AP) activity and D-dimer in patients with hepatocellular carcinoma before and after operation and their clinical significance. Methods: The plasma PLG and α2-AP activity in 20 patients with hepatocellular carcinoma before and after operation were detected by chromogenic substrate method. Meanwhile, the content of plasma D-Dimer was detected by colloidal gold double antibody sandwich method. Results: The activity of plasma PLG and α2-AP in patients with liver cancer was significantly lower than that of the normal control (P <0.05). The plasma D-Dimer level in patients with liver cancer was significantly higher than that in the normal control group (P <0.01). Postoperative plasma levels of PLG and α2-AP were significantly higher than those preoperatively (P <0.05), and plasma D-Dimer levels were significantly lower than those preoperatively (P <0.01). Conclusion: The activation of fibrinolytic system exists in patients with liver cancer and improves with the improvement of operation condition.