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[目的]分析川南地区肾病综合征的复发与咽部微生态的相关性。[方法]选择川南地区肾病综合征患者150例,其中复发及初发患者各75例,并与75例健康人对照,检测口咽部微生态状况。[结果]复发组患者细菌菌群密集度明显增高(F=90.27,P﹤0.001)。在致病菌检出率中,白色念珠菌和乙链菌是复发组患者的主要致病菌,占36%(白色念珠菌χ2=15.08,乙溶血性链菌χ2=17.40,P﹤0.001)。[结论]肾病综合征的复发主要与咽部的乙链菌和白色念珠菌感染有关,这为预防肾病综合征的复发提供了理论依据。
[Objective] To analyze the relapse of nephrotic syndrome in southern Sichuan and pharyngeal microecology. [Method] 150 cases of nephrotic syndrome in southern Sichuan were selected, including 75 cases of recurrence and initial onset, and compared with 75 cases of healthy people to detect the oropharyngeal microecological status. [Results] The bacterial flora in relapse group was significantly higher (F = 90.27, P <0.001). Candida albicans and β-streptozotocin were the major pathogens in patients with recurrent disease (36% of Candida albicans χ2 = 15.08, χ2 = 17.40, P <0.001) . [Conclusion] The relapse of nephrotic syndrome is mainly related to the infection of B-streptococcus and Candida albicans in the pharynx, which provides a theoretical basis for preventing the recurrence of nephrotic syndrome.