论文部分内容阅读
目的探讨人类表皮生长因子受体基因(HER-2)及癌胚抗原(CEA)在胃印戒细胞癌组织中的表达及临床意义。方法选取80例胃印戒细胞癌患者作为实验组,40例萎缩性胃炎患者作为对照组。应用免疫组织化学法检测两组组织中HER-2及CEA的表达,并分析其表达与胃印戒细胞癌临床特征的关系。结果 HER-2及CEA在胃印戒细胞癌组织中的阳性表达率分别为43.8%和63.8%,明显高于萎缩性胃炎组,差异具有统计学意义(P<0.01)。HER-2在2期~4期胃印戒细胞癌组织中的阳性表达率为70.5%,明显高于1期的阳性率(11.1%),P<0.05。有淋巴结转移组的HER-2阳性表达率(78.8%)明显高于无淋巴结转移组(19.1%),P<0.01。HER-2的表达与肿瘤大小、侵犯深度无关(P>0.05)。CEA的表达与淋巴结转移相关(P<0.05),而与临床分期无关(P>0.05)。结论 HER-2及CEA的表达可能与胃印戒细胞癌的发生、发展及淋巴结转移有关。
Objective To investigate the expression of human epidermal growth factor receptor gene (HER-2) and carcinoembryonic antigen (CEA) in gastric signet-ring cell carcinoma and its clinical significance. Methods Eighty patients with signet-ring cell carcinoma were selected as experimental group and 40 patients with atrophic gastritis as control group. Immunohistochemistry was used to detect the expression of HER-2 and CEA in both groups, and the relationship between the expression of HER-2 and CEA was analyzed. Results The positive rates of HER-2 and CEA in gastric signet-ring cell carcinoma were 43.8% and 63.8%, respectively, which were significantly higher than those in atrophic gastritis group (P <0.01). The positive rate of HER-2 in stage 2 to stage 4 gastric signet-ring cell carcinomas was 70.5%, which was significantly higher than that in stage 1 (11.1%), P <0.05. The positive rate of HER-2 expression in lymph node metastasis group (78.8%) was significantly higher than that in non-lymph node metastasis group (19.1%), P <0.01. The expression of HER-2 was not related to tumor size and invasion depth (P> 0.05). CEA expression was correlated with lymph node metastasis (P <0.05), but not with clinical stage (P> 0.05). Conclusion The expression of HER-2 and CEA may be related to the occurrence and development of gastric signet-ring cell carcinoma and lymph node metastasis.