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作者鉴于部分具有不良预后特点的睾丸非精原细胞癌对以顺氯氟铂(DDP)为主药的常规联合化疗方案效果欠佳的状况,同时已知DDP的疗效随剂量的增加而提高,然而肾脏毒性也随之增加。为了达到提高疗效又不增加肾脏毒性的目的,作者设计了由DDP、VLB、BLM和VP-16(鬼臼乙叉甙)四药组成的新方案,称为PVeBV方案。其主要特点是DDP剂量为常规方案的DDP剂量的二倍、同时高剂量的DDP与3％的盐水250ml混和输法,具体方案如下:DDP 40mg/m~2iv~*连用五天;VP-16 100mg/m~2 iv连用五天;VLB 0.2mg/kg iv 第一天;BLM 30mg/次iv每周一次连用9周;每三周重复。(~*溶于250ml3％氯化钠液中用药)
In view of the fact that some non-spermatogial carcinomas of the testis with poor prognostic characteristics are ineffective for conventional combined chemotherapy with cisplatin (DDP) as the main drug, it is also known that the efficacy of DDP increases with increasing doses. However, kidney toxicity also increases. In order to improve the efficacy without increasing the toxicity of the kidneys, the authors designed a new protocol consisting of DDP, VLB, BLM, and VP-16 (podophylline) as a PVeBV regimen. Its main feature is that the dose of DDP is twice the DDP dose of the conventional protocol, while the high dose of DDP is mixed with 3% saline 250ml. The specific protocol is as follows: DDP 40mg/m~2iv~* for 5 days; VP-16 100 mg/m~2 iv for five days; VLB 0.2 mg/kg iv for the first day; BLM 30 mg/time for iv once per week for 9 weeks; repeated every three weeks. (~* dissolved in 250ml 3% sodium chloride solution)