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目的观察IgM及IgG在肺炎支原体(MP)感染中的变化特点。方法对60例MP感染患者和34例健康对照组的血清学标本同时进行IgM和IgG检测。在治疗前的急性期、治疗后1周和治疗后2周,检测2组的IgG滴度和IgM阳性率。结果MP感染组IgM和IgG阳性率高于健康对照组,差异有统计学意义(P<0.01)。在MP感染组中,IgG滴度在治疗后1周比治疗前显著升高(P<0.01),而在治疗后2周与治疗后1周相比无显著性差异(P>0.05),MP感染组中,IgM阳性率在治疗后1周比治疗前显著升高(P<0.01),在治疗后2周比治疗后1周显著下降(P<0.01)。结论治疗前IgM和IgG检测有助于MP感染的诊断,且在治疗后1周检测MP-IgM和MP-IgG比急性期检测阳性率更高;在MP感染的治疗监测中,检测MP-IgM比MP-IgG更优。
Objective To observe the changes of IgM and IgG in Mycoplasma pneumoniae (MP) infection. Methods Serum samples of 60 patients with MP infection and 34 healthy controls were tested for IgM and IgG simultaneously. In the acute phase before treatment, 1 week after treatment and 2 weeks after treatment, IgG titer and IgM positive rate in two groups were detected. Results The positive rates of IgM and IgG in MP infection group were significantly higher than those in healthy control group (P <0.01). In MP infection group, IgG titer increased significantly (P <0.01) one week after treatment and no significant difference (P> 0.05) between two weeks after treatment and one week after treatment In the infected group, the positive rate of IgM was significantly increased 1 week after treatment (P <0.01), and significantly decreased 1 week after the treatment (P <0.01). Conclusion The detection of IgM and IgG before treatment contributes to the diagnosis of MP infection. The detection of MP-IgM and MP-IgG at 1 week after treatment is more positive than that of acute phase. In the treatment of MP infection, MP-IgM Better than MP-IgG.