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目的了解四川省医院抗菌药物使用情况。方法对四川省23所医院2011年6月25日00:00-24:00的在院患者抗菌药物使用情况进行横断面调查。结果 23所医院27 144例住院患者调查日抗菌药物使用率为42.4%,各医院日使用率范围为24.3%~63.3%。以治疗用药为使用目的者占63.8%,使用1种抗生素的占72.2%。36.9%的治疗性用药患者送标本培养。随着医院规模的增大,抗菌药物使用率逐渐降低(χ2=411.834,P=0.000);随着地区经济水平的提高,医院抗菌药物使用率逐渐降低(χ2=500.093,P=0.000)。抗菌药物种类使用前3位依次为其他β-内酰胺类抗生素、青霉素类抗生素和第3代头孢菌素类抗生素。结论四川省抗菌药物使用情况总体较为合理,仍需继续降低住院患者不合理的抗菌药物使用,加强抗菌药物临床应用管理。
Objective To understand the use of antibacterials in hospitals in Sichuan Province. Methods A cross-sectional survey of the use of antimicrobial agents in 23 hospitals in Sichuan Province on June 25, 2011 from 00: 00-24: 00 was conducted. Results The use of antibacterials was 42.4% on 27 144 inpatients in 23 hospitals and 24.3% -63.3% on each hospital day. 63.8% were for therapeutic purposes and 72.2% were for one type of antibiotic. 36.9% of patients with therapeutic drug delivery culture. With the increase of the size of the hospital, the usage of antibacterials decreased gradually (χ2 = 411.834, P = 0.000). With the improvement of the regional economic level, the antibacterials utilization rate decreased gradually (χ2 = 500.093, P = 0.000). The top 3 antibacterials were followed by other β-lactam antibiotics, penicillin antibiotics and third-generation cephalosporin antibiotics. Conclusion The overall use of antimicrobial agents in Sichuan Province is relatively reasonable. It is still necessary to continue to reduce the unreasonable use of antimicrobial agents in hospitalized patients and to strengthen the clinical management of antimicrobial agents.