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β-内酰胺抗生素联用的效果不断引起人们的注意,例如,解释抑菌剂和杀菌剂联合产生协同作用的异常现象。不过,这些效果与不同的β-内酰胺抗生素联用和对不同的菌种有关。因为某些联用仅对特殊的细菌有协同作用或相加作用。本文综述了各种β-内酰胺抗生素联用产生的协同作用和拮抗作用及其产生的原因,并试图确定治疗应用。β-内酰胺抗生素的活性在于抑制与酶有关的不同的细胞浆膜。这些酶被β-内酰胺抗生素酰化,称为青霉素结合蛋白。为了达
The effect of the combination of β-lactam antibiotics continues to draw attention, for example, explaining the synergistic effect of the combination of bacteriostat and bactericide. However, these effects are associated with different β-lactam antibiotics and to different strains. Because some combinations have synergistic or additive effects on specific bacteria only. This article reviews the synergistic and antagonistic effects of various β-lactam antibiotics and their causes, and attempts to determine the therapeutic use. The activity of [beta] -lactam antibiotics lies in the inhibition of different cytoplasmic membranes associated with the enzyme. These enzymes are acylated by [beta] -lactam antibiotics, known as penicillin-binding proteins. In order to reach