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肿瘤化疗失败的原因之一是多药抗药性的产生。小鼠艾氏腹水瘤对阿霉素产生多药抗药性后,可以耐受5mg·kg~(-1)的剂量。为了更清楚的了解抗药现象,我们测定了小鼠艾氏腹水瘤对阿霉素产生抗药性后肝,心及瘤细胞中谷胱甘肽—S—转移酶(GST)的活性;并比较了抗药瘤细胞及敏感瘤细胞的活性。
One of the causes of tumor chemotherapy failure is the emergence of multi-drug resistance. Ehrlich ascites tumor of adriamycin multi-drug resistance, can tolerate the dose of 5mg · kg ~ (-1). In order to understand the drug resistance more clearly, we measured the activity of glutathione-S-transferase (GST) in the liver, heart and tumor cells of Ehrlich ascites tumor-resistant to doxorubicin. Anti-tumor cells and sensitive tumor cells activity.