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目的研究活血化瘀中药制剂腰痛康治疗血瘀型腰痛的作用机理。方法把40只成年白兔制成模拟神经根炎，随机分为空白对照组、腰痛康煎剂组、腰痛康膏剂组、阳性对照药腰痛宁组。给药的3个组自造模术后第2天开始每天灌胃给药。于给药第7天和第15天采血作血液流变学检查，于给药第10天采血作血清NO浓度检测。结果与空白对照组相比，腰痛康煎剂组和膏剂组给药7天时其血浆粘度、纤维蛋白原、血沉有不同程度的降S氏；给药15天时其全血粘度、红细胞聚积有不同程度的降低；给药10天时其血清NO显著降低。结论腰痛康可以改善血液的粘浓状态，降低血清NO浓度，促使神经根炎症的消除和组织修复，从而达到止痛的效果。
Objective To study the mechanism of treatment of blood stasis type lumbago by traditional Chinese medicine Huoxuehuayu. Methods Forty adult white rabbits were made into simulated radiculitis and randomly divided into blank control group, Yaotongkang decoction group, Yaotongkang ointment group and positive control Yaotongning group. The three groups to be administered were intragastrically administered daily from the second day after the model was established. On the 7th and 15th days of administration, blood was collected for hemorheology examination, and on the 10th day of administration, blood was taken for serum NO concentration detection. Results Compared with the blank control group, the plasma viscosity, fibrinogen, and erythrocyte sedimentation rate in the Yaotongkang decoction group and the ointment group decreased to different degrees when administered for 7 days; the viscosity of whole blood and the accumulation of red blood cells were different when administered for 15 days. The degree of reduction; serum NO was significantly reduced at 10 days after administration. Conclusion Yaoxuekang can improve the state of blood viscosity, reduce serum NO concentration, promote the elimination of nerve root inflammation and tissue repair, so as to achieve analgesic effect.