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目的探讨三磷酸肌醇受体(IP3R)在妊娠期高血压患者胎盘组织中的表达及临床意义。方法 28例妊娠期高血压患者作为研究组,同时期正常妊娠孕妇28例作为对照组,分析比较两组三磷酸肌醇受体表达水平。结果研究组患者胎盘组织三磷酸肌醇受体表达强度相比较对照组明显上升(P<0.05)。结论妊娠期高血压患者胎盘组织中三磷酸肌醇受体具有较高表达,用其进行妊娠期高血压检测对于临床诊治具有重要作用。
Objective To investigate the expression and clinical significance of inositol 1,4,5 - trisphosphate receptor (IP3R) in placenta of hypertensive patients with gestational hypertension. Methods 28 cases of hypertensive patients with gestational hypertension as a research group, the same period 28 cases of normal pregnant women as a control group, analysis and comparison of two groups of inositol 1,4,5 - trisphosphate receptor expression levels. Results The intensity of inositol 1,4,5-trisphosphate receptor expression in placenta of study group was significantly higher than that of control group (P <0.05). Conclusion The placental tissue of hypertensive patients with gestational hypertension placental inositol 1,4,5 - trisphosphate receptor is highly expressed, with its detection of gestational hypertension for clinical diagnosis and treatment has an important role.