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对饲养在SPF环境中,鼠龄6个月的47只T细胞缺乏的BALB/c(nu/nu)裸鼠及26只T细胞正常的BALB/c(+/nu)杂合子小鼠进行病理观察,发现两只BALB/c(nu/nu)裸鼠生长自发性肿瘤。病理诊断分别为浆细胞样淋巴细胞型淋巴瘤和B免疫母细胞型淋巴瘤。肿瘤发生率为4.26％。而BALB/c(+/nu)杂合子小鼠未见肿瘤生长。
47 BALB / c (nu / nu) nude mice and 26 T-cell-normal BALB / c (+ / nu) heterozygous mice that were housed in 47 T-cell deficient mice Observations revealed that two BALB / c (nu / nu) nude mice grew spontaneous tumors. Pathological diagnosis were plasmacytoid lymphocytic lymphoma and B immunoblastic lymphoma. The incidence of cancer was 4.26%. However, no tumor growth was observed in BALB / c (+ / nu) heterozygous mice.