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目的研究假奓包叶的抗菌活性成分。方法在抗菌药理活性跟踪下,应用多种色谱技术进行化合物分离,运用波谱分析法和化学手段鉴定其结构。结果从具有明显抗菌活性的部位分离得到了8个化合物,分别鉴定为洋芹素(1)、木樨草素(2)、穗花杉双黄酮(3)、丹皮酚(4)、脱镁叶绿素a(5)、132S-羟基脱镁叶绿素a(6)、β-谷甾醇(7)、豆甾醇(8)。结论化合物4-6为首次从假奓包叶属植物中得到。药理实验表明,化合物1-6有一定的抑制大肠杆菌的活性;化合物4-6为首次从假奓包叶属植物中得到。药理实验表明,化合物1-6有一定的抑制大肠杆菌的活性;其中化合物3-6还具有抑制金黄色葡萄球菌的活性,化合物4活性最显著。
Objective To study the antimicrobial active ingredients of pseudonym Methods The compounds were isolated by a variety of chromatographic techniques following the antibacterial pharmacological activity. Their structures were identified by spectral analysis and chemical methods. Results Eight compounds were isolated from the sites with obvious antimicrobial activity and identified as cetiin (1), clodronomycin (2), biflavone (3), paeonol (4), pheophytin a (5), 132S-hydroxy-pheophytin a (6), β-sitosterol (7), stigmasterol (8). Conclusion Compounds 4-6 were obtained from the foliage plants for the first time. Pharmacological experiments show that compounds 1-6 have a certain inhibition of E. coli activity; compounds 4-6 for the first time from the pseudobulium accessions. Pharmacological experiments show that compounds 1-6 have a certain inhibition of E. coli activity; of which compounds 3-6 also inhibit the activity of Staphylococcus aureus, Compound 4 activity of the most significant.