目的 :探讨人骨肉瘤组织中P2 7蛋白的表达及其与骨肉瘤发生、发展和病理分型的关系。方法 :采用免疫组化SP法 ,检测 1 0例骨软骨瘤组织和 30例骨肉瘤组织 (骨母细胞型 1 4例 ,软骨母细胞型 5例 ,纤维母细胞型 8例 ,混合型 3例 ;高分化 7例 ,低分化 2 3例 )中P2 7蛋白的表达情况。结果 :骨肉瘤组织中P2 7蛋白阳性表达率为33.33% (1 0 /30 ) ,低于骨软骨瘤中的 80 % (8/1 0 ) (P <0 .0 5 )。骨肉瘤高分化组P2 7蛋白阳性表达率为 71 .4 3% (5 /7) ,高于低分化组的 2 1 .74 % (5 /2 3) (P <0 .0 5 )。骨肉瘤各病理亚型间P2 7蛋白阳性表达率差异无统计学意义 (P >0 .0 5 )。结论 :P2 7蛋白表达与骨肉瘤发生、发展密切相关 ,可作为判断骨肉瘤恶性程度的一个指标 Objective: To investigate the expression of P2 7 protein in human osteosarcoma and its relationship with the occurrence, development and pathological type of osteosarcoma. Methods: Immunohistochemical SP method was used to detect osteochondroma in 10 cases and osteosarcoma in 30 cases (14 cases of osteoblastic cell type, 5 cases of chondroblast cell type, 8 cases of fibroblast type and 3 cases of mixed type ; 7 cases of well-differentiated, poorly differentiated 23 cases) P2 7 protein expression. Results: The positive rate of P2 7 protein in osteosarcoma was 33.33% (10/30), which was lower than 80% (8/1 0) in osteochondroma (P <0.05). The positive rate of P2 7 protein in well-differentiated osteosarcoma group was 71.4% (5/7), which was higher than that in poorly differentiated group (21.34%, P <0.05). There was no significant difference in the positive rate of P2 7 protein between different pathological subtypes of osteosarcoma (P> 0.05). Conclusion: The expression of P2 7 protein is closely related to the occurrence and development of osteosarcoma and may be used as an index to judge the malignant degree of osteosarcoma