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目的探讨血浆同型半胱氨酸(Hcy)水平对女性高血压患者冠状动脉病变及左心室功能的影响。方法 354例女性高血压患者分为H型高血压组(血浆Hcy≥10μmol/L,240例)和非H型高血压组(血浆Hcy<10μmol/L,114例),比较两组患者冠状动脉病变特点及左心室功能。结果H型高血压组患者冠状动脉Gensini总分、左心室重量指数、左心室室壁张力高于非H型高血压组,而左心室射血分数低于非H型高血压组(P<0.05)。两组患者左心室等容舒张时间、E峰值和E/A比较均有统计学差异(P<0.05),而A峰值、e’峰值、a’峰值、e’/a’、E/e’比较差异无统计学意义(P>0.05)。结论女性H型高血压患者和非H型高血压患者在冠状动脉病变、左心室收缩功能及部分舒张功能上存在差异;血浆Hcy水平增高是女性高血压患者冠状动脉粥样硬化及左心室功能减退的危险因素。
Objective To investigate the effect of plasma homocysteine (Hcy) level on coronary artery disease and left ventricular function in female patients with hypertension. Methods 354 hypertensive patients with Hypertension were divided into two groups: Hypertension group (Hcy≥10μmol / L, 240 cases) and non Hypertension group (Hcy <10μmol / L, 114 cases) Lesions and left ventricular function. Results The Gensini score, left ventricular mass index and left ventricular wall tension were significantly higher in patients with Hypertension than those without Hypertension, while the left ventricular ejection fraction was lower than those without Hypertension (P <0.05 ). The left ventricular isovolumetric relaxation time, E peak and E / A of the two groups were significantly different (P <0.05), while the A peak, e ’peak, a’ peak, e ’/ a’, E / e ’ The difference was not statistically significant (P> 0.05). Conclusion There is a difference in coronary artery lesion, left ventricular systolic function and partial diastolic function between female Hypertension patients and non Hypertensive patients. The elevated plasma Hcy level is a marker of coronary atherosclerosis and left ventricular dysfunction in female patients with hypertension Risk factors.