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目的研究宝安区妇女感染HPV的优势亚型,为宫颈癌防治提供依据。方法利用HPV基因芯片检测技术检验我院妇科门诊样本HPV亚型。结果 1049例病人中,HPV感染264例,阳性率25.17%。其中高危型(HPV16、18、31、33、35、39、45、51、52、53、56、58、59、66、68、73、83、和MM4)162例,占感染者81.44%;低危型(HPV11、6、42、43)49例,占感染者18.56%。二组感染率比较差异有统计学意义;264例感染HPV优势亚型HPV52,其次依次为16、43、58、68、18、53型;<30岁及≥30岁两年龄段HPV感染率比较差异无统计学意义;组间优势亚型分布比较HPV53在<30岁年龄组明显增加,其他优势亚型分布比较差异无统计学意义;单一亚型感染239例,占90.52%。结论高危亚型、单一亚型为主要常见感染类型;HPV基因分型诊断在宫颈癌筛查和防治中具有重要意义。
Objective To study the predominant subtype of HPV in women in Bao’an District and provide the basis for prevention and treatment of cervical cancer. Methods HPV genotypes were used to test HPV subtypes of gynecology clinics in our hospital. Results Among the 1049 patients, HPV infection was found in 264 cases, the positive rate was 25.17%. Among them, 162 cases were high risk type (HPV16,18,31,33,35,39,45,51,52,53,56,58,59,66,68,73,83, and MM4), accounting for 81.44% of infected persons. Low-risk type (HPV11,6,42,43) 49 cases, accounting for 18.56% of infected persons. There were significant differences in infection rates between the two groups; 264 cases were HPV subtype HPV52, followed by 16,43,58,68,18,53 cases; HPV infection rates in both <30 years and 30 years old groups There was no significant difference between the two groups. The distribution of dominant subtypes in HPV53 group was significantly increased in <30 years old group, while there was no significant difference in the distribution of other subtypes. There were 239 cases (90.52%) with single subtype infection. Conclusion High-risk subtypes and single subtypes are the most common types of infection. The diagnosis of HPV genotyping is of great importance in the screening and prevention of cervical cancer.