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研究证实 ,内毒素激活核转录因子κＢ(ｎｕｃｌｅａｒｔｒａｎｓｃｉｐｔｉｏｎｆａｃｔｏｒｋａｐｐａＢ ,ＮＦ -κΒ) ,进而诱导前炎性因子大量生成 ,是内毒素休克和急性肺损伤的关键发病学环节。防止ＮＦ -κＢ激活或抑制其活性已成为治疗急性肺损伤和内毒素休克的新途径。?
Studies have shown that endotoxin activates nuclear factor kappa B (NF-κB), which in turn induces the production of a large number of proinflammatory cytokines, which is the key pathogenesis of endotoxic shock and acute lung injury. Preventing or inhibiting NF-κB activation has become a new approach to the treatment of acute lung injury and endotoxic shock. ?