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应用大鼠实验性心肌梗塞模型，观察小檗碱（Ｂｅｒｂｅｒｉｎｅ，Ｂｅｒ）对缺血心肌的保护作用。结果表明；Ｂｅｒ（总量１２ｍｇ·ｋｇ－１，ｉＰ）能显著缩小大鼠冠脉结扎后２４ｈ的心肌梗塞范围，减少血清游高脂肪酸的增高，降低梗塞后病理性Ｑ波的发生率，提示Ｂｅｒ对缺血心肌具有保护作用。Ｐ＜０．０１（ｎ＝１０），３０６±８７μｍｏｌ·Ｌ－１（ｎ＝１０），与正常血清比差异无显著性（Ｐ＞０．０５），ＮＳ组冠脉结扎后１ｈ，４ｈ血清ＦＦＡ明显增高，与结扎前正常血清比差异有显著性（Ｐ＜０．０５）。Ｂｅｒ和Ｖｅｒ组与ＮＳ组比均能降低冠脉结扎后１ｈ，４ｈ血清ＦＦＡ的增高（Ｐ＜０．０５）。结果见表２。表２Ｂｅｒ对大鼠冠脉结扎后１ｈ，４ｈ血清ＦＦＡ的影响，ｎ＝１０；与ＮＳ组比较，Ｐ＜０．０５２．３对大鼠心肌梗塞后病理性Ｑ波的影响各组大鼠结扎后４ｈ，２４ｈ胸前导联（Ｖ４）心电图病理性Ｑ波的出现率见表３。结果表明，Ｂｅｒ与Ｖｅｒ相似，能降低Ｑ波的发生率（Ｐ＜０．０５）。表３Ｂｅｒ对大鼠冠脉结扎后４ｈ，２４ｈＥＣＧＱ波发生率的影晌（ｎ＝１０）Ｓｈａｍ＝伪结扎组，与ＮＳ组比较，＊Ｐ＜０．０５，Ｐ＜０．０１３讨论ＭＩＳ是影响心功能的主要因素之一，Ｍ?
The model of experimental myocardial infarction in rats was used to observe the protective effect of berberine on ischemic myocardium. The results showed that Ber (total 12 mg · kg-1, ip) significantly reduced myocardial infarct size at 24 hours after coronary ligation in rats, decreased serum elevated fatty acids and decreased the incidence of post-infarction pathological Q wave, suggesting Ber has a protective effect on ischemic myocardium. There was no significant difference between normal NS group and control group (P> 0.05). There was no significant difference between normal NS group and control group (P> 0.05) FFA was significantly higher than that before ligation, there was a significant difference (P <0.05). Compared with the NS group, Ber and Ver group decreased the serum FFA level 1h and 4h after coronary artery ligation (P <0.05). The results are shown in Table 2. Table 2Ber on rat serum after 1h, 4h FFA, n = 10; compared with the NS group, P <0.052.3 after myocardial infarction in rats with pathological Q wave ligation in rats ligation After 4h, 24h chest lead (V4) ECG pathological Q waves appear in Table 3. The results showed that Ber and Ver similar, can reduce the incidence of Q wave (P <0.05). TABLE 3Ber Effect of echocardiography on the incidence of echocardiography in 4h and 24h after coronary artery occlusion (n = 10) Sham = sham group, compared with NS group, * P <0.05, P <0.013 DISCUSSION MIS One of the main factors of cardiac function, M?