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目的探讨游离脂肪酸(Free fatty acid,FFA)和糖化血红蛋白(glycosylated hemoglobin,Hb A1c)联合监测与子痫前期(Preeclampsia,PE)糖脂代谢异常的相关性。方法选取99例子痫前期患者(PE组)和93例正常妊娠孕妇(对照组),分别检测FFA、Hb A1c、空腹血糖(Fasting plasma glucose,FPG)、甘油三酯(Triglycerides,TG)、胆固醇(Cholesterol,TCH),并对结果进行分析比较。结果 PE组与对照组比较,重度PE组和轻度PE组相比较,FFA、Hb A1c、FPG、TG、TCH差异均有统计学意义(P<0.05)。PE组FFA与Hb A1c呈正相关(r=0.768),且FFA和Hb A1c浓度与PE病情轻重呈正相关(r=0.668、0.528)。结论高FFA和Hb A1c血症与PE糖脂代谢异常存在密切的关系,联合监测对了解PE糖脂代谢异常及其病情发展、预后判断具有重要的临床指导意义。
Objective To investigate the relationship between free fatty acid (FFA) and glycosylated hemoglobin (Hb A1c) in monitoring the abnormal glucose and lipid metabolism in preeclampsia (Preeclampsia, PE). Methods Ninety-nine patients with preeclampsia (PE group) and 93 normal pregnant women (control group) were enrolled in this study. FFA, Hb A1c, fasting plasma glucose (FPG), triglycerides (TG), cholesterol Cholesterol, TCH), and the results were analyzed and compared. Results Compared with control group, there were significant differences in FFA, Hb A1c, FPG, TG and TCH between PE group and control group (P <0.05). There was a positive correlation between FFA and Hb A1c in PE group (r = 0.768). The concentrations of FFA and Hb A1c were positively correlated with the severity of PE (r = 0.668,0.528). Conclusions There is a close relationship between high FFA and HbA1c hyperlipidemia and abnormalities of PE glycolipid metabolism. The combined monitoring is of great clinical significance in understanding the abnormalities of the metabolism of PE, lipid metabolism and prognosis.