自然杀伤细胞(natural killer cells)是一种非T、非B、无粘附力、无吞噬功能,不需致敏即能对多种靶细胞产生非特异性杀伤作用的淋巴细胞。七十年代初Rosenberg、Tak-asugi和Herberman等在研究中发现,正常未经免疫的供体(如献血者)的淋巴细胞当与不同种类的细胞株或肿瘤细胞混合时,可以引起一种显著的非特异性的细胞毒反应,称为自然的或自发的细胞介导的细胞毒反应(natural orspontaneous cell-mediated cytotoxicity’SCMC)。随后又在啮齿动物中观察到类似现象。因此,在人和动物体内存在一个具有SCMC潜能的细胞群的观点被大家所接受。可 Natural killer cells are non-T, non-B, non-adhesive, phagocytic, non-sensitized lymphocytes that produce nonspecific killing on a wide range of target cells. In the early 1970s, Rosenberg, Tak-asugi, and Herberman et al found in the study that lymphocytes from normal, unimmunized donors (such as donors) when mixed with different cell types or tumor cells can cause a significant Of non-specific cytotoxic reactions, known as natural or spontaneous cell-mediated cytotoxicity (natural orspontaneous cell-mediated cytotoxicity ’SCMC). A similar phenomenon was observed later in rodents. Therefore, it is accepted by everyone that there is a cell population having SCMC potential in humans and animals. can