现在已经认识到哺乳类动物的晶体内含有数种可溶性抗原性蛋白质(即Pre-α-,α-,β-,β_(?)-和γ-晶体蛋白),这些蛋白质可以刺激产生相应的抗体和细胞介导免疫。对异种晶体蛋白可呈阳性体液免疫反应,首先是由Uhlenhuth(1903)所发现的。近年来Rahi等(1977)又应用免疫荧光试验,免疫过氧化酶试验,淋巴细胞转化试验进行了研究。作者应用现代免疫技术研究发现不同动物免疫反应幅度的差异与单纯注射抗原或同时应用含分枝杆菌的佐剂有关。同种的而不是异种物质看来好像类似自身物质,故此有的作者曾试图用同种晶体蛋白使动物发生免疫作用来研究对眼组织的反应,但未成功(Romer和Gebb1912)。有关同种晶体蛋白的抗原性以后又经过很多作者的验证,发现同种晶体抗原组织匀浆不能导致任何抗体反应(Halbert等1965),只有同时使用完全弗氏佐剂才能发现免疫反应。作者回顾过去研究进展情况注意到同种晶体抗原体液和细胞免疫反应迄今尚无深入的研究。为此,作者应用现代免疫方法对同种 It has now been recognized that mammalian crystals contain several soluble antigenic proteins (ie, Pre-alpha, alpha, beta, beta, and gamma-crystal proteins) that stimulate the production of the corresponding antibodies And cell-mediated immunity. A positive humoral immune response to xeno-crystal proteins was first found by Uhlenhuth (1903). In recent years, Rahi et al. (1977) applied immunofluorescence assay, immunoperoxidase assay and lymphocyte transformation assay. The authors applied modern immunoassay techniques to find differences in the magnitude of the immune response in different animals when injected with antigen alone or in combination with adjuvants containing mycobacteria. The same species, rather than the foreign species, appears to resemble its own substance, so some authors have attempted to study the effects on ocular tissues by immunizing animals with the same crystal protein but failed (Romer and Gebb 1912). The antigenicity of the same kind of crystal protein has been verified by many authors after that, and it was found that homogeneous crystal antigen homogenization did not lead to any antibody reaction (Halbert et al., 1965). Only complete Freund’s adjuvant was used to detect the immune response. The authors review the past research progress noted that the same type of crystalloid antigen and humoral immune response to date there is no in-depth study. To this end, the author applies modern immunization methods to the same species