一氧化碳(CO)是急性中毒导致死亡最常见的窒息性气体,大量进入体内的外源性 CO 能引起以中枢神经系统和心血管系统功能损害为主的多脏器损害。其中最严重的是部分患者表现为急性期意识障碍恢复后(“假逾期”),出现以神经精神系统损害为主的急性 CO 中毒迟发性脑病(DNS)。急性 CO 中毒性 DNS 病患者经过临床“假逾期”再次出现以认知和学习记忆功能障碍为主的神经精神症状,表现为“双相”的临床过程特点,患者以痴呆表现为主,可伴有精神和意识障碍、锥体及锥体外系功能障碍等。目前仍然没有有效方法防治急性 CO 中毒 DNS 的发生,该病发病机制一直是国内外研究人员的热点问题,虽然已经取得很大进展,但到目前为止即使是急性 CO 中毒性脑病的 Carbon monoxide (CO) is the most common asphyxiant gas that causes acute death from acute poisoning. Exogenous CO that enters the body in large quantities can cause multiple organ damage, which is predominantly impaired by central nervous system and cardiovascular system function. The most serious of these patients were those with acute CO poisoning and delayed encephalopathy (DNS) after the recovery of acute phase disturbance of consciousness (“false overdue”) and neuropsychiatric system. Acute CO poisoning patients with DNS after clinical “false overdue ” again to cognitive and learning and memory dysfunction-based neuropsychiatric symptoms, manifested as “biphasic ” characteristics of the clinical process, patients with dementia manifested as Lord, may be associated with mental and disturbance of consciousness, cone and extrapyramidal disorders and so on. There is still no effective way to prevent and treat the occurrence of acute CO poisoning DNS. The pathogenesis of this disease has been a hot issue both at home and abroad. Although great progress has been made, so far, even acute CO poisoning encephalopathy