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目的:对比研究溃疡性结肠炎(UC)与克罗恩病(CD)的病理形态学特点。方法:将诊断为UC和CD的181例患者病例资料进行回顾性分析,根据实验室与临床资料,比较其镜下及组织学表现的不同。结果:经过结肠镜下比较发现,病变部位、分布状态、纵行溃疡、环形溃疡、阿弗他溃疡、结节样增生、肠腔狭窄及鹅卵石征等项目在两组患者间的比较其差异显著,而其他类型则无差异。两组患者的病理结果比较发现,炎症侵犯肌层、绒毛状结构增生、隐窝炎或脓肿、非干酪性肉芽肿、隐窝扭曲、杯状细胞减少以及潘氏细胞化生等项目组间差异显著。结论:根据UC和CD的病理学特点,在诊断UC和CD时需要将内镜下和显微镜下结肠病变的特征进行综合分析,以便做出更为准确的诊断。
Objective: To compare the pathomorphological characteristics of ulcerative colitis (UC) and Crohn’s disease (CD). METHODS: A retrospective analysis of 181 cases of patients diagnosed with UC and CD was performed. The differences in microscopic and histological findings were compared based on laboratory and clinical data. Results: Comparing the results of colonoscopy, there were significant differences between the two groups in the lesion location, distribution, longitudinal ulcer, ring ulcer, aphthous ulcer, nodular hyperplasia, intestinal stenosis and pebbles sign , While other types are not different. Two groups of patients compared the pathological findings found that inflammatory invasion of the muscle layer, villous structure hyperplasia, cryptorrhea or abscess, non-cheese granuloma, crypt twisting, goblet cell reduction and Paneth cells metaplasia and other items between the differences Significant. Conclusion: According to the pathological features of UC and CD, the features of endoscopic and microscopic colonic lesions need to be analyzed comprehensively in the diagnosis of UC and CD in order to make a more accurate diagnosis.