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本共文对7例MNNG诱发的分化较好的大鼠胃腺癌进行了组织化学和超微结构的研究。结果表明,本组胃腺癌细胞乳酸脱氢酶(LDH)和萄葡糖—6—磷酸脱氢酶(G6PDH)活性比正常胃粘膜上皮细胞高,而琥珀酸脱氢酶(SDH)与正常胃粘膜上皮细胞无显著差别。透射电镜观察,本组胃腺癌具有下列特点:1.细胞间连接复杂;2.癌细胞内线粒体较多,微丝增多;3.癌细胞核畸形显著,有许多不规则突起,呈蝌蚪状、乳头状或蕈状等。
In this paper, the histochemical and ultrastructural studies of gastric adenocarcinoma in rats with better differentiation induced by MNNG were performed. The results showed that the activity of lactate dehydrogenase (LDH) and glucose-6-phosphate dehydrogenase (G6PDH) in gastric adenocarcinoma cells was higher than that in normal gastric epithelial cells, while succinate dehydrogenase (SDH) and normal stomach were higher in this group. There was no significant difference in mucosal epithelial cells. Transmission electron microscope observation showed that the gastric adenocarcinoma of this group had the following characteristics: 1. The connection between cells was complicated; 2. There were more mitochondria in the cancer cells and microfilaments increased; 3. The nuclear aberrations of the cancer cells were significant, there were many irregular processes, and there were verrucous and papillae. Shaped or sickle and so on.