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目的:尼莫地平治疗高血压性脑出血的临床疗效。方法:90例高血压脑出血患者随机分为实验组(45例)和对照组(45例),对照组仅采用常规治疗,实验组在常规治疗的基础上采用尼莫地平进行治疗,比较两组临床疗效、治疗前后的临床神经功能缺损评分、临床残疾评分以及血肿和水肿带体积改变。结果:实验组和对照组的治疗有效率为73.33%和42.22%,差异具有统计学意义(P<0.05)。实验组和对照组治疗前、后临床神经功能缺损评分分别为(18.58±3.06)、(12.31±2.74)和(18.28±2.97)、(15.22±2.72),实验组和对照组治疗前、后临床残疾评分分别为(38.93±3.37)、(61.57±3.03)和(37.51±4.962)和(43.48±7.19),实验组和对照组治疗前、后的血肿体积分别为(17.23±5.48)cm3、(7.93±3.33)cm3和(17.60±5.46)cm3、(10.97±4.25)cm3,实验组和对照组治疗前、后的水肿带体积分别为(7.73±3.20)cm3、(4.21±1.60)cm3和(7.83±3.19)cm3和(5.67±1.82)cm3,所有患者治疗后各指标均优于治疗前,治疗后两组组间比较均有有显著性(P<0.01)。结论:尼莫地平能够明显的减少血肿体积和水肿带的体积,提高治疗的效果,减少脑出血患者发生神经功能缺损和残疾的可能。
Objective: Nimodipine in the treatment of hypertensive intracerebral hemorrhage clinical efficacy. Methods: Ninety patients with hypertensive intracerebral hemorrhage were randomly divided into experimental group (n = 45) and control group (n = 45). The control group was treated with conventional therapy only. The experimental group was treated with nimodipine on the basis of routine treatment. Group clinical efficacy, clinical neurological deficit scores before and after treatment, clinical disability score and volume changes of hematoma and edema zone. Results: The effective rates of the experimental group and the control group were 73.33% and 42.22%, respectively, with statistical significance (P <0.05). The scores of clinical neurological deficits before and after treatment in the experimental group and the control group were (18.58 ± 3.06), (12.31 ± 2.74) and (18.28 ± 2.97) and (15.22 ± 2.72) respectively. The experimental group and the control group (38.93 ± 3.37), (61.57 ± 3.03) and (37.51 ± 4.962) and (43.48 ± 7.19) respectively, the volume of hematoma in the experimental group and the control group before and after treatment were (17.23 ± 5.48) cm3 and 7.93 ± 3.33 cm3 and (17.60 ± 5.46) cm3 and (10.97 ± 4.25) cm3, respectively. The volumes of edema in experimental group and control group before and after treatment were (7.73 ± 3.20) cm3, (4.21 ± 1.60) cm3 and 7.83 ± 3.19 cm3 and 5.67 ± 1.82 cm3, respectively. All the indexes of all patients were better than before treatment, and there was significant difference between the two groups after treatment (P <0.01). Conclusion: Nimodipine can significantly reduce the volume of hematoma and the volume of edema zone, improve the therapeutic effect and reduce the possibility of neurological deficits and disability in patients with cerebral hemorrhage.