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糖萼蛋白(glycocalicin,GC)是血小板膜糖蛋白(GP)Ibα的可溶性蛋白溶解片段,是血小板膜损伤的新的特异性分子标志物。为明确弥散性血管内凝血(DIC)过程中血小板减少的确切原因,作者用夹心法酶联免疫吸附测定检测了36例实体瘤患者的血浆糖萼蛋白(PGC)浓度。包括胃癌12例,肺癌6例,结肠癌4例,胆囊癌4例,胰腺癌4例,卵巢癌、乳癌、肝癌各2例。
Glycocalcin (GC), a soluble protein-soluble fragment of platelet glycoprotein (GP) Ibα, is a new specific molecular marker of platelet membrane damage. To determine the exact cause of thrombocytopenia during disseminated intravascular coagulation (DIC), the authors examined the plasma concentrations of glycocalyx (PGC) in 36 patients with solid tumors by sandwich enzyme-linked immunosorbent assay. Including gastric cancer in 12 cases, lung cancer in 6 cases, colon cancer in 4 cases, gallbladder cancer in 4 cases, pancreatic cancer in 4 cases, ovarian cancer, breast cancer, liver cancer in 2 cases.