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目的 :探讨肝硬化患者 AST/AL T比值的变化 ,以了解其与病情严重程度的关系及在判断预后中的作用。方法 :应用奥林巴斯 AU6 0 0全自动生化分析仪检测肝硬化患者及健康对照组的 AST与 AL T,计算其比值。结果 :与健康对照组比较 ,肝硬化患者 AST/AL T比值明显增高 (P<0 .0 1 ) ,且随着 Child- Pugh分级的升高而递增 ,各级间比较差异有显著性 (P<0 .0 1 )。相关分析显示 ,肝硬化患者血清 AST/AL T比值与 Child- Pugh积分呈正相关 (rs=0 .387,P<0 .0 1 )。结论 :AST/AL T比值可以作为了解肝硬化患者肝脏储备功能的一个较易观测的指标 ,对临床观察病情 ,指导治疗及判断预后方面有一定的作用。
Objective: To investigate the changes of AST / ALT ratio in patients with cirrhosis and to understand its relationship with the severity of the disease and its role in prognosis. Methods: Olympus AU6 0 0 automatic biochemical analyzer was used to detect AST and ALT in cirrhotic patients and healthy controls, and the ratio was calculated. Results: The AST / ALT ratio in cirrhotic patients was significantly higher than that in healthy controls (P <0.01), and increased with the increase of Child-Pugh score, and there was significant difference among all levels (P <0 .0 1). Correlation analysis showed that the serum AST / ALT ratio in patients with cirrhosis was positively correlated with Child-Pugh score (rs = 0.387, P <0.01). Conclusion: The AST / ALT ratio can be used as a more easily observable index to understand the liver reserve function in cirrhotic patients, and has a certain effect on the clinical observation of the disease, guiding treatment and prognosis.