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目的:探讨伴或不伴焦虑特征的抑郁症患者杏仁核各亚区低频振幅(amplitude of low frequency fluctuation，ALFF)的差异及其与各组间临床特征的相关性。方法:选取在南京脑科医院就诊的抑郁症患者144例，符合DSM-Ⅳ-TR中抑郁的诊断标准及排除标准。同时招募62位人口学特征相匹配的健康对照，进行3.0 T静息态磁共振扫描，并使用汉密尔顿抑郁量表(HAMD-17)评估患者的严重程度。在Matlab软件中使用DPARSFA工具包对磁共振数据进行预处理后，使用rest工具包对不同组被试计算杏仁核各亚区ALFF值，按照患者的焦虑/躯体化因子分是否≥7分，分为焦虑组(n n＝65)和非焦虑组(n n＝79)。在SPSS 19.0软件中以单因素方差分析分别比较三组受试杏仁核三个亚区：基底侧杏仁核(laterobasal，LB)、中央杏仁核(centromedial，CM )、皮层下杏仁核(superficial，SF) ALFF值的组间差异，并在组间进行事后比较(n P<0.05，Bonferroni多重比较矫正后，n P<0.0083)。将患者组差异有统计学意义的脑区ALFF值与焦虑/躯体化因子分进行相关分析。n 结果:与非焦虑组比较(左侧CM：1.12±0.21，左LB：1.01±0.26，左SF：1.49±0.46)，焦虑性抑郁患者左侧CM(1.22±0.18)、左侧LB(1.16±0.33)、左SF(1.90±0.66)亚区ALFF值升高，差异有统计学意义(均n P<0.01，均通过Bonferroni矫正)。相关分析发现焦虑性抑郁症患者左侧中央杏仁核ALFF值与焦虑/躯体化因子分呈正相关(n r＝0.473，n P＝0.008)。n 结论:左侧杏仁核功能异常可能是抑郁症患者出现焦虑特征的神经病理基础，其中左侧CM亚区的功能异常可以作为焦虑/躯体化严重程度的潜在生物学标记物。“,”Objective:To explore the difference of amplitude of low frequency fluctuation(ALFF) in amygdala subregions between anxious depression patients and non-anxious depression patients, and its correlation with clinical features.Methods:A total of 144 patients with depression diagnosed by DSM-Ⅳ-TR criteria and exclusion criteria in Nanjing Brain Hospital, meanwhile 62 healthy controls with matching demographic characteristic were recruited.All subjects were scanned with 3.0 T fMRI scanner.The severity of the patients was assessed by Hamilton depression scale (HAMD-17). After preprocessing magnetic resonance data with DPARSFA toolkit in Matlab, ALFF values of each subregion of amygdala were calculated with rest toolkit for different groups of subjects.Patients were divided into anxious group (n n=65) and non-anxious group (n n=79) according to whether their anxiety/somatization factor score was greater than 7.In SPSS 19.0, ANOVA was used to calculate the difference of ALFF in amygdala subregion in three groups, then two-sample n t test was used to find the differences between each other group (Bonferroni multiple comparison correction, n P<0.05). Pearson correlation analysis was performed between ALFF values of brain regions with significant differences and clinical factors.n Results:Compared with the non-anxious group(left central amygdala: 1.12±0.21, left dorsolateral nucleus: 1.01±0.26, left subcortical amygdala: 1.49±0.46), the ALFF values of the left central amygdala(1.22±0.18), left dorsolateral nucleus(1.16±0.33) and left subcortical amygdala(1.90±0.66) in anxious depression group were significantly different (all n P<0.01, Bonferroni corrected). Correlation analysis showed that the ALFF value of the left central amygdala in patients with anxious depression was positively correlated with the anxiety/somatization factor score (n r=0.473, n P=0.008).n Conclusion:Abnormal left amygdala function in patients with depression may be the neuropathological basis of anxiety, among which the abnormal left central nucleus brain area may be related to the severity of anxiety/somatization.