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目的 从组织学角度结合HPV原位杂交检测探讨尖锐湿疣和假性湿疣及相关病变的临床病理特点。方法 收集 196例活检标本 ,随机抽取典型尖锐湿疣 70例 ,假性湿疣 30例 ,相关病变 10例作HPV 6B、11原位杂交检测分析 ,观察HE组织切片。结果 本组材料中 ,70例 (10 0 % )典型尖锐湿疣和 3例 (10 % )假性湿疣HPV表达阳性 ,相关病变均表达阴性 ,尖锐湿疣和相关病变HPV表达具有显著差异性 (P <0 .0 0 1)。结论 HPV原位杂交检测阳性与临床病理密切相关 ,而假性湿疣与HPV感染无关
Objective To investigate the clinicopathological features of condylomata acuminata, condylomata acuminata and their related lesions in combination with HPV in situ hybridization. Methods A total of 196 biopsies were collected and 70 cases of typical condyloma acuminatum, 30 cases of pseudotumor genital warts and 10 cases of related lesions were collected for detection by HPV 6B and 11 in situ hybridization. HE tissue sections were observed. Results In this study, 70 cases (100%) of typical condyloma acuminatum and 3 cases (10%) of condylomata acuminatum were positive for HPV expression, all of them had negative expression of HPV. There was significant difference in HPV expression between genital warts and related lesions (P < 0 .0 0 1). Conclusion The positive results of HPV in situ hybridization are closely related to the clinical pathology, whereas the false condyloma acuminatum is not related to HPV infection