论文部分内容阅读
同型半胱氨酸（ Hcy）是甲硫氨酸代谢的一个中间产物，其在体内有3条代谢途径，并受遗传、环境、营养、生理等多种因素的影响。在呼吸系统常见疾病中，Hcy水平也有明显升高，主要是通过氧化应激、损伤血管内皮细胞、增强凝血功能、刺激血管平滑肌细胞增殖、细胞毒作用、改变基因组甲基化水平等机制参与疾病的发生、发展。 Hcy水平一定程度上可反映病情的严重程度，同时降低Hcy水平可能在疾病预防、病程转归及预后等方面有重要意义。“,”Homocysteine( Hcy) is an intermediate metabolite of methionine metabolism ,which has three metabolic pathways in the body and is influenced by heredity,environment,nutrition,physiology,etc.Hcy has a high level in respiratory diseases.It triggers the pathogenesis of diseases via multiple mechanisms including oxidative stress, lesions of vascular endothelial cells, dysfunction of coagulation, proliferation of vascular smooth muscle cells,cytotoxicity and genomic hypomethylation,etc.Hcy may reflect the severity of the disea-ses to some extent,while lowering the Hcy level may be important in the prevention ,turnover and prognosis of the diseases.