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目的探讨Galectin-3基因多态性与宫颈癌易感性和预后的关系。方法选取2010年1月至2014年3月海南医学院附属医院妇科收治的宫颈癌患者120例为观察组,120例健康人群为对照组,用聚合酶链反应限制性片段长度多态性(PCR-RFLP)方法对Galectin-3基因rs4652位点进行基因分型。结果携带CC+CA型患者罹患宫颈癌的风险增加,等位基因C为危险基因,且CC+CA型患者5年生存率低。结论 Galectin-3基因rs4652位点等位基因C是罹患宫颈癌的危险基因,并影响预后复发。
Objective To investigate the relationship between Galectin-3 gene polymorphism and cervical cancer susceptibility and prognosis. Methods From January 2010 to March 2014, 120 cases of cervical cancer admitted to the Affiliated Hospital of Hainan Medical College were selected as observation group and 120 healthy people as control group. Polymerase chain reaction restriction fragment length polymorphism -RFLP) was used to genotype rs4652 of Galectin-3 gene. Results Patients with CC + CA had an increased risk of developing cervical cancer, allele C was a risk gene, and patients with CC + CA had a lower 5-year survival rate. Conclusion The allele C of rs4652 in Galectin-3 gene is a risk gene for cervical cancer and affects prognosis.