论文部分内容阅读
已发现醛糖还原酶(ＡＬＲ2)基因位于染色体7ｑ35,其2.1ｋｂ上游双核苷酸重复多态性与中国人2型糖尿病及高加索人1型糖尿病中糖尿病性视网膜病变及糖尿病肾病的早期发病相关。本研究在大样本日本2型糖尿病人中同时检测了作为ＡＬＲ2组织表达标志的红细胞内ＡＬＲ2的蛋白浓度和Ａ
It has been found that the aldose reductase (ALR2) gene is located on chromosome 7q35 and its 2.1 kb upstream dinucleotide repeat polymorphism is associated with the early onset of diabetic retinopathy and diabetic nephropathy in Chinese type 2 diabetes and Caucasian type 1 diabetes. In this study, a large sample of Japanese type 2 diabetic patients simultaneously detected ALR2 tissue expression of erythrocyte ALR2 protein concentration and A