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目的研究LyGDI在肺癌组织中的表达及临床意义。方法用免疫蛋白印迹法分析肺癌及癌旁正常组织中LyGDI蛋白的表达情况。结果37份配对组织标本中,LyGDI在29份肺癌组织中的表达明显高于其相应的癌旁正常组织,差异有统计学意义(P<0.05)。肺癌组织中的小细胞癌(SCLC)与非小细胞癌(NSCLC)LyGDI表达的差异无统计学意义(P>0.05)。在NSCLC中,LyGDI的表达与分化程度(P<0.01)、淋巴结转移(P<0.05)有关,与性别(P>0.05)、年龄(P>0.05)、组织学分类(P>0.05)、分期(P>0.05)无关。结论肺癌组织中LyGDI蛋白的表达与组织分化程度及淋巴结转移存在相关性,与临床病理类型无相关性。LyGDI可能与肺癌的发生、发展有关。
Objective To study the expression of LyGDI in lung cancer and its clinical significance. Methods The expression of LyGDI protein in lung cancer tissues and adjacent normal tissues was analyzed by immunoblotting. Results The expression of LyGDI in 29 lung cancer tissues was significantly higher than that in corresponding normal tissues of 37 paired tissues (P <0.05). There were no significant differences in the expression of LyGDI between SCLC and non-small cell lung cancer (NSCLC) in lung cancer (P> 0.05). The expression of LyGDI was correlated with the degree of differentiation (P <0.01) and lymph node metastasis (P <0.05) in NSCLC, but not with gender (P> 0.05), age (P> 0.05), histological classification (P> 0.05) has nothing to do. Conclusions The expression of LyGDI protein in lung cancer is correlated with the degree of differentiation and lymph node metastasis, but not with clinicopathological types. LyGDI may be related to the occurrence and development of lung cancer.